Members of the division are actively engaged in both basic and clinical research. The following summarizes predominantly funded activities.

Current grant-supported basic research (listed in alphabetical order) includes:

• Dr. Veronica Catanese's laboratory is engaged in investigation of the pathogenesis of HIV protease-inhibitor associated lipodystrophy and hyperlipidemia using both molecular, biological and clinical/translational approaches. She and her group also work on dissecting the pathways signaling the hypertrophic vs. sclerotic phenotypes in mesangial cells, characterizing and isolating an IGF-dependent BP4 protease, and defining the mechanism by which IGF-I promotes TGF-beta activation in the kidney.
• Dr. David Kleinberg's laboratory has a long-standing and productive interest in control of mammary gland development. He and his group were responsible for demonstrating that growth hormone and prolactin are separate molecules in human beings, and that prolactin is an important hormone in clinical endocrine disorders, such as pituitary tumors. They then went on to demonstrate that mammary development was importantly controlled by growth hormone and IGF-1, while the role of prolactin was mainly that of lactogenesis. Recently, prostate development has also been shown to depend on growth hormone and IGF-1. Dr. Kleinberg's work has been continuously funded by NIH, the Veteran's Administration, or DOD.
• Dr. David Ron's work is focused on the cellular response to proteotoxic stress, and the impact of malfolded proteins on diseases such as type 2 diabetes. It is anticipated that identification of components of the cellular response to proteotoxic stress will provide the scaffold upon which to build pharmacological tools that will enable the manipulation of these responses to favorable ends.
• Dr. Herbert Samuels' laboratory is nationally and internationally recognized for its investigation of the mechanism of action of thyroid hormone, and conserved elements of gene regulation by members of the nuclear hormone receptor superfamily. He and his group have defined DNA-protein interactions and protein-protein interactions that regulate control of gene transcription in response to thyroid hormone and retinoic acid. Dr. Samuels' interests extend to delineation of basic molecular mechanisms involved in thyroid hormone resistance syndromes and interaction of the T3-T3 receptor complex with the HIV-1 promoter.

Faculty members of the Division of Endocrinology and Metabolism are also active in grant-supported clinical investigations (listed in alphabetical order).