Yazici Outcomes Research Unit

Principal Investigator:
Theodore Pincus, MD

Departments of Medicine (Rheumatology) and Hospital for Joint Diseases and Medicine (Rheumatology-HJD)

Research Information
Formerly Professor of Medicine and Rheumatology at Vanderbilt University, has joined the NYUHJD faculty to lead clinical outcomes research. Dr. Pincus was the first to demonstrate the long-term consequences of rheumatoid arthritis, which led to modern approaches to treatment.

This page contains a listing of articles authored or co-authored by Dr. Theodore Pincus.
(This list may take a moment to appear.)

1:

Pincus T, Yazici Y, Sokka T.

Are excellent systematic reviews of clinical trials useful for patient care?

Nat Clin Pract Rheumatol. 2008 May 6. [Epub ahead of print] No abstract available.

PMID: 18461062 [PubMed - as supplied by publisher]

2:

Sokka T, Envalds M, Pincus T.

Treatment of rheumatoid arthritis: a global perspective on the use of antirheumatic drugs.

Mod Rheumatol. 2008 Apr 25. [Epub ahead of print]

PMID: 18437286 [PubMed - as supplied by publisher]

3:

Yazici Y, Bergman M, Pincus T.

Time to Score Quantitative Rheumatoid Arthritis Measures: 28-Joint Count, Disease Activity Score, Health Assessment Questionnaire (HAQ), Multidimensional HAQ (MDHAQ), and Routine Assessment of Patient Index Data (RAPID) Scores.

J Rheumatol. 2008 Apr;35(4):603-9. Epub 2008 Mar 1.

PMID: 18322993 [PubMed - in process]

4:

Naranjo A, Sokka T, Descalzo MA, Calvo-Alén J, Hørslev-Petersen K, Luukkainen RK, Combe B, Burmester GR, Devlin J, Ferraccioli G, Morelli A, Hoekstra M, Majdan M, Sadkiewicz S, Belmonte M, Holmqvist AC, Choy E, Tunc R, Dimic A, Bergman M, Toloza S, Pincus T; the QUEST-RA Group.

Cardiovascular disease in patients with rheumatoid arthritis: results from the QUEST-RA study.

Arthritis Res Ther. 2008 Mar 6;10(2):R30. [Epub ahead of print]

PMID: 18325087 [PubMed - as supplied by publisher]

5:

Chung CP, Oeser A, Solus JF, Avalos I, Gebretsadik T, Shintani A, Raggi P, Sokka T, Pincus T, Stein CM.

Prevalence of the metabolic syndrome is increased in rheumatoid arthritis and is associated with coronary atherosclerosis.

Atherosclerosis. 2008 Feb;196(2):756-63. Epub 2007 Jan 30.

PMID: 17266963 [PubMed - indexed for MEDLINE]

6:

Pincus T, Amara I, Segurado OG, Bergman M, Koch GG.

Relative efficiencies of physician/assessor global estimates and patient questionnaire measures are similar to or greater than joint counts to distinguish adalimumab from control treatments in rheumatoid arthritis clinical trials.

J Rheumatol. 2008 Feb;35(2):201-5. Epub 2007 Nov 15.

PMID: 18050378 [PubMed - indexed for MEDLINE]

7:

Sokka T, Häkkinen A, Kautiainen H, Maillefert JF, Toloza S, Mørk Hansen T, Calvo-Alen J, Oding R, Liveborn M, Huisman M, Alten R, Pohl C, Cutolo M, Immonen K, Woolf A, Murphy E, Sheehy C, Quirke E, Celik S, Yazici Y, Tlustochowicz W, Kapolka D, Skakic V, Rojkovich B, Müller R, Stropuviene S, Andersone D, Drosos AA, Lazovskis J, Pincus T; QUEST-RA Group.

Physical inactivity in patients with rheumatoid arthritis: data from twenty-one countries in a cross-sectional, international study.

Arthritis Rheum. 2008 Jan 15;59(1):42-50.

PMID: 18163412 [PubMed - indexed for MEDLINE]

8:

Asanuma Y, Chung CP, Oeser A, Solus JF, Avalos I, Gebretsadik T, Shintani A, Raggi P, Sokka T, Pincus T, Stein CM.

Serum osteoprotegerin is increased and independently associated with coronary-artery atherosclerosis in patients with rheumatoid arthritis.

Atherosclerosis. 2007 Dec;195(2):e135-41. Epub 2007 Jun 14.

PMID: 17570371 [PubMed - indexed for MEDLINE]

9:

Avalos I, Chung CP, Oeser A, Gebretsadik T, Shintani A, Kurnik D, Raggi P, Sokka T, Pincus T, Stein CM.

Increased augmentation index in rheumatoid arthritis and its relationship to coronary artery atherosclerosis.

J Rheumatol. 2007 Dec;34(12):2388-94. Epub 2007 Nov 15.

PMID: 18050386 [PubMed - indexed for MEDLINE]

10:

Sokka T, Kautiainen H, Toloza S, Mäkinen H, Verstappen SM, Lund Hetland M, Naranjo A, Baecklund E, Herborn G, Rau R, Cazzato M, Gossec L, Skakic V, Gogus F, Sierakowski S, Bresnihan B, Taylor P, McClinton C, Pincus T; QUEST-RA Group.

QUEST-RA: quantitative clinical assessment of patients with rheumatoid arthritis seen in standard rheumatology care in 15 countries.

Ann Rheum Dis. 2007 Nov;66(11):1491-6. Epub 2007 Apr 5.

PMID: 17412740 [PubMed - indexed for MEDLINE]

11:

Pincus T, Yazici Y, Bergman M, Maclean R, Harrington T.

A proposed continuous quality improvement approach to assessment and management of patients with rheumatoid arthritis without formal joint counts, based on quantitative routine assessment of patient index data (RAPID) scores on a multidimensional health assessment questionnaire (MDHAQ).

Best Pract Res Clin Rheumatol. 2007 Aug;21(4):789-804.

PMID: 17678835 [PubMed - indexed for MEDLINE]

12:

Pincus T, Yazici Y, Bergman M.

A practical guide to scoring a Multi-Dimensional Health Assessment Questionnaire (MDHAQ) and Routine Assessment of Patient Index Data (RAPID) scores in 10-20 seconds for use in standard clinical care, without rulers, calculators, websites or computers.

Best Pract Res Clin Rheumatol. 2007 Aug;21(4):755-87.

PMID: 17678834 [PubMed - indexed for MEDLINE]

13:

Pincus T, Sokka T.

Can a Multi-Dimensional Health Assessment Questionnaire (MDHAQ) and Routine Assessment of Patient Index Data (RAPID) scores be informative in patients with all rheumatic diseases?

Best Pract Res Clin Rheumatol. 2007 Aug;21(4):733-53.

PMID: 17678833 [PubMed - indexed for MEDLINE]

14:

Pincus T, Sokka T.

A three-page Standard Protocol to Evaluate Rheumatoid Arthritis (SPERA) for efficient capture of essential data from patients and health professionals in standard clinical care and clinical research.

Best Pract Res Clin Rheumatol. 2007 Aug;21(4):677-85.

PMID: 17678829 [PubMed - indexed for MEDLINE]

15:

Pincus T, Yazici Y, Sokka T.

Quantitative measures of rheumatic diseases for clinical research versus standard clinical care: differences, advantages and limitations.

Best Pract Res Clin Rheumatol. 2007 Aug;21(4):601-28. Review.

PMID: 17678823 [PubMed - indexed for MEDLINE]

16:

Pincus T, Huizinga TW, Yazici Y.

N-of-1 trial of low-dose methotrexate and/or prednisolone in lieu of anti-CCP, MRI, or ultrasound, as first option in suspected rheumatoid arthritis?

J Rheumatol. 2007 Feb;34(2):250-2. No abstract available.

PMID: 17304647 [PubMed - indexed for MEDLINE]

17:

Pincus T.

Patient questionnaires and formal education as more significant prognostic markers than radiographs or laboratory tests for rheumatoid arthritis mortality--limitations of a biomedical model to predict long-term outcomes.

Bull NYU Hosp Jt Dis. 2007;65 Suppl 1:S29-36. Review. No abstract available.

PMID: 17708743 [PubMed - indexed for MEDLINE]

18:

Pincus T.

A multidimensional health assessment questionnaire (MDHAQ) for all patients with rheumatic diseases to complete at all visits in standard clinical care.

Bull NYU Hosp Jt Dis. 2007;65(2):150-60.

PMID: 17581111 [PubMed - indexed for MEDLINE]

19:

Pincus T, Tugwell P.

Shouldn't standard rheumatology clinical care be evidence-based rather than eminence-based, eloquence-based, or elegance-based?

J Rheumatol. 2007 Jan;34(1):1-4. No abstract available.

PMID: 17216670 [PubMed - indexed for MEDLINE]

20:

Pincus T, Gibofsky A, Harrington JT.

Improving survival in inflammatory rheumatic diseases: a neglected goal?

Curr Rheumatol Rep. 2006 Dec;8(6):401-3. No abstract available.

PMID: 17092437 [PubMed - indexed for MEDLINE]

21:

Pincus T, Yazici Y, van Vollenhoven R.

Why are only 50% of courses of anti-tumor necrosis factor agents continued for only 2 years in some settings? Need for longterm observations in standard care to complement clinical trials.

J Rheumatol. 2006 Dec;33(12):2372-5. No abstract available.

PMID: 17143975 [PubMed - indexed for MEDLINE]

22:

Pincus T, Sokka T.

Quantitative measures to assess patients with rheumatic diseases: 2006 update.

Rheum Dis Clin North Am. 2006 Dec;32 Suppl 1:29-36. Review. No abstract available.

PMID: 17410699 [PubMed - indexed for MEDLINE]

23:

Pincus T, Chung C, Segurado OG, Amara I, Koch GG.

An index of patient reported outcomes (PRO-Index) discriminates effectively between active and control treatment in 4 clinical trials of adalimumab in rheumatoid arthritis.

J Rheumatol. 2006 Nov;33(11):2146-52. Epub 2006 Oct 15.

PMID: 17080518 [PubMed - indexed for MEDLINE]

24:

Sokka T, Kautiainen H, Hannonen P, Pincus T.

Changes in Health Assessment Questionnaire disability scores over five years in patients with rheumatoid arthritis compared with the general population.

Arthritis Rheum. 2006 Oct;54(10):3113-8.

PMID: 17009231 [PubMed - indexed for MEDLINE]

25:

Pincus T.

The DAS is the most specific measure, but a patient questionnaire is the most informative measure to assess rheumatoid arthritis.

J Rheumatol. 2006 May;33(5):834-7. No abstract available.

PMID: 16652413 [PubMed - indexed for MEDLINE]

26:

Pincus T, Yazici Y, Bergman M.

Saving time and improving care with a multidimensional health assessment questionnaire: 10 practical considerations.

J Rheumatol. 2006 Mar;33(3):448-54. No abstract available.

PMID: 16511913 [PubMed - indexed for MEDLINE]

27:

Pincus T, Sokka T.

Evidence-based practice and practice-based evidence.

Nat Clin Pract Rheumatol. 2006 Mar;2(3):114-5. No abstract available.

PMID: 16932666 [PubMed - indexed for MEDLINE]

28:

Chung CP, Oeser A, Avalos I, Gebretsadik T, Shintani A, Raggi P, Sokka T, Pincus T, Stein CM.

Utility of the Framingham risk score to predict the presence of coronary atherosclerosis in patients with rheumatoid arthritis.

Arthritis Res Ther. 2006;8(6):R186.

PMID: 17169159 [PubMed - indexed for MEDLINE]

29:

Pincus T.

Advantages and limitations of quantitative measures to assess rheumatoid arthritis: joint counts, radiographs, laboratory tests, and patient.

Bull NYU Hosp Jt Dis. 2006;64(1-2):32-9. Review.

PMID: 17121487 [PubMed - indexed for MEDLINE]

30:

Pincus T, Yazici Y, Yazici H, Kavanaugh AF, Kremer JM, Wolfe F.

Radiographic benefit without clinical improvement in infliximab-treated patients with rheumatoid arthritis: comment on the article by Smolen et al.

Arthritis Rheum. 2005 Dec;52(12):4044-5; author reply 4045-7. No abstract available.

PMID: 16320353 [PubMed - indexed for MEDLINE]

31:

Wolfe F, Michaud K, Pincus T, Furst D, Keystone E.

The disease activity score is not suitable as the sole criterion for initiation and evaluation of anti-tumor necrosis factor therapy in the clinic: discordance between assessment measures and limitations in questionnaire use for regulatory purposes.

Arthritis Rheum. 2005 Dec;52(12):3873-9.

PMID: 16320335 [PubMed - indexed for MEDLINE]

32:

Wolfe F, Michaud K, Pincus T.

A composite disease activity scale for clinical practice, observational studies, and clinical trials: the patient activity scale (PAS/PAS-II).

J Rheumatol. 2005 Dec;32(12):2410-5.

PMID: 16331773 [PubMed - indexed for MEDLINE]

33:

Chung CP, Oeser A, Raggi P, Gebretsadik T, Shintani AK, Sokka T, Pincus T, Avalos I, Stein CM.

Increased coronary-artery atherosclerosis in rheumatoid arthritis: relationship to disease duration and cardiovascular risk factors.

Arthritis Rheum. 2005 Oct;52(10):3045-53.

PMID: 16200609 [PubMed - indexed for MEDLINE]

34:

Pincus T, Sokka T, Kautiainen H.

Further development of a physical function scale on a MDHAQ [corrected] for standard care of patients with rheumatic diseases.

J Rheumatol. 2005 Aug;32(8):1432-9. Erratum in: J Rheumatol. 2005 Nov;32(11):2280.

PMID: 16078316 [PubMed - indexed for MEDLINE]

35:

Wolfe F, Michaud K, Pincus T.

Preliminary evaluation of a visual analog function scale for use in rheumatoid arthritis.

J Rheumatol. 2005 Jul;32(7):1261-6.

PMID: 15996062 [PubMed - indexed for MEDLINE]

36:

Pincus T, Sokka T, Kautiainen H.

Patients seen for standard rheumatoid arthritis care have significantly better articular, radiographic, laboratory, and functional status in 2000 than in 1985.

Arthritis Rheum. 2005 Apr;52(4):1009-19.

PMID: 15818706 [PubMed - indexed for MEDLINE]

37:

Pincus T, Amara I, Koch GG.

Continuous indices of core data set measures in rheumatoid arthritis clinical trials: lower responses to placebo than seen with categorical responses with the American College of Rheumatology 20% criteria.

Arthritis Rheum. 2005 Apr;52(4):1031-6.

PMID: 15818698 [PubMed - indexed for MEDLINE]

38:

Pincus T, Wolfe F.

Patient questionnaires for clinical research and improved standard patient care: is it better to have 80% of the information in 100% of patients or 100% of the information in 5% of patients?

J Rheumatol. 2005 Apr;32(4):575-7. No abstract available.

PMID: 15801008 [PubMed - indexed for MEDLINE]

39:

Pincus T, Wang X, Chung C, Sokka T, Koch GG.

Patient preference in a crossover clinical trial of patients with osteoarthritis of the knee or hip: face validity of self-report questionnaire ratings.

J Rheumatol. 2005 Mar;32(3):533-9. Erratum in: J Rheumatol. 2005 May;32(5):966.

PMID: 15742449 [PubMed - indexed for MEDLINE]

40:

Pincus T, Sokka T.

Quantitative measures and indices to assess rheumatoid arthritis in clinical trials and clinical care.

Rheum Dis Clin North Am. 2004 Nov;30(4):725-51, vi. Review.

PMID: 15488690 [PubMed - indexed for MEDLINE]

41:

Pincus T, Sokka T.

Clinical trials in rheumatic diseases: designs and limitations.

Rheum Dis Clin North Am. 2004 Nov;30(4):701-24, v-vi. Review.

PMID: 15488689 [PubMed - indexed for MEDLINE]

42:

Wolfe F, Michaud K, Pincus T.

Development and validation of the health assessment questionnaire II: a revised version of the health assessment questionnaire.

Arthritis Rheum. 2004 Oct;50(10):3296-305.

PMID: 15476213 [PubMed - indexed for MEDLINE]

43:

Yazici Y, Pincus T, Kautiainen H, Sokka T.

Morning stiffness in patients with early rheumatoid arthritis is associated more strongly with functional disability than with joint swelling and erythrocyte sedimentation rate.

J Rheumatol. 2004 Sep;31(9):1723-6.

PMID: 15338490 [PubMed - indexed for MEDLINE]

44:

Pincus T.

Will racial and ethnic disparities in health be resolved primarily outside of standard medical care?

Ann Intern Med. 2004 Aug 3;141(3):224-5. No abstract available.

PMID: 15289222 [PubMed - indexed for MEDLINE]

45:

Boers M, Dijkmans B, Gabriel S, Maradit-Kremers H, O'Dell J, Pincus T.

Making an impact on mortality in rheumatoid arthritis: targeting cardiovascular comorbidity.

Arthritis Rheum. 2004 Jun;50(6):1734-9. Review. No abstract available.

PMID: 15188348 [PubMed - indexed for MEDLINE]

46:

Chung C, Escalante A, Pincus T.

How Many Versions and Translations of the HAQ and Its Variants Are Needed?: It Doesn't Matter-Just Use One.

J Clin Rheumatol. 2004 Jun;10(3):101-104. No abstract available.

PMID: 17043479 [PubMed - as supplied by publisher]

47:

Pincus T.

Add-on or step-up trials in rheumatoid arthritis: comment on the article by Boers.

Arthritis Rheum. 2004 Apr;50(4):1351; author reply 1351-2. No abstract available.

PMID: 15077322 [PubMed - indexed for MEDLINE]

48:

Pincus T, Keysor J, Sokka T, Krishnan E, Callahan LF.

Patient questionnaires and formal education level as prospective predictors of mortality over 10 years in 97% of 1416 patients with rheumatoid arthritis from 15 United States private practices.

J Rheumatol. 2004 Feb;31(2):229-34.

PMID: 14760789 [PubMed - indexed for MEDLINE]

49:

Pincus T.

Guidelines for monitoring of methotrexate therapy: "evidence-based medicine" outside of clinical trials.

Arthritis Rheum. 2003 Oct;48(10):2706-9. Review. No abstract available.

PMID: 14558072 [PubMed - indexed for MEDLINE]

50:

Pincus T, Sokka T.

Quantitative measures for assessing rheumatoid arthritis in clinical trials and clinical care.

Best Pract Res Clin Rheumatol. 2003 Oct;17(5):753-81. Review.

PMID: 12915156 [PubMed - indexed for MEDLINE]

51:

DeWalt DA, Pincus T.

The legacies of Rudolf Virchow: cellular medicine in the 20th century and social medicine in the 21st century.

Isr Med Assoc J. 2003 Jun;5(6):395-7. No abstract available.

PMID: 12841007 [PubMed - indexed for MEDLINE]

52:

Sokka T, Pincus T.

Most patients receiving routine care for rheumatoid arthritis in 2001 did not meet inclusion criteria for most recent clinical trials or american college of rheumatology criteria for remission.

J Rheumatol. 2003 Jun;30(6):1138-46.

PMID: 12784382 [PubMed - indexed for MEDLINE]

53:

Jawaheer D, Seldin MF, Amos CI, Chen WV, Shigeta R, Etzel C, Damle A, Xiao X, Chen D, Lum RF, Monteiro J, Kern M, Criswell LA, Albani S, Nelson JL, Clegg DO, Pope R, Schroeder HW Jr, Bridges SL Jr, Pisetsky DS, Ward R, Kastner DL, Wilder RL, Pincus T, Callahan LF, Flemming D, Wener MH, Gregersen PK; North American Rheumatoid Arthritis Consortium.

Screening the genome for rheumatoid arthritis susceptibility genes: a replication study and combined analysis of 512 multicase families.

Arthritis Rheum. 2003 Apr;48(4):906-16.

PMID: 12687532 [PubMed - indexed for MEDLINE]

54:

Wolfe F, Pincus T, Thompson AK, Doyle J.

The assessment of rheumatoid arthritis and the acceptability of self-report questionnaires in clinical practice.

Arthritis Rheum. 2003 Feb 15;49(1):59-63.

PMID: 12579594 [PubMed - indexed for MEDLINE]

55:

Sokka T, Pincus T.

Eligibility of patients in routine care for major clinical trials of anti-tumor necrosis factor alpha agents in rheumatoid arthritis.

Arthritis Rheum. 2003 Feb;48(2):313-8.

PMID: 12571838 [PubMed - indexed for MEDLINE]

56:

Sokka T, Pincus T.

Contemporary disease modifying antirheumatic drugs (DMARD) in patients with recent onset rheumatoid arthritis in a US private practice: methotrexate as the anchor drug in 90% and new DMARD in 30% of patients.

J Rheumatol. 2002 Dec;29(12):2521-4.

PMID: 12465145 [PubMed - indexed for MEDLINE]

57:

Pincus T, Gibofsky A, Weinblatt ME.

Urgent care and tight control of rheumatoid arthritis as in diabetes and hypertension: better treatments but a shortage of rheumatologists.

Arthritis Rheum. 2002 Apr;46(4):851-4. Review. No abstract available.

PMID: 11953958 [PubMed - indexed for MEDLINE]

58:

Pincus T.

Limitations of randomized clinical trials in chronic diseases: explanations and recommendations.

Adv Mind Body Med. 2002 Winter;18(2):14-21. Review. No abstract available.

PMID: 12629874 [PubMed - indexed for MEDLINE]

59:

Pincus T, Sokka T, Stein CM.

Are long-term very low doses of prednisone for patients with rheumatoid arthritis as helpful as high doses are harmful?.

Ann Intern Med. 2002 Jan 1;136(1):76-8. No abstract available.

PMID: 11777366 [PubMed - indexed for MEDLINE]

60:

Willerson JT, Trelstad RL, Pincus T, Levy SB, Wolff SM.

Subcellular Localization of Salmonella enteritidis Endotoxin in Liver and Spleen of Mice and Rats.

Infect Immun. 1970 May;1(5):440-445.

PMID: 16557755 [PubMed - as supplied by publisher]