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An immediate postdoctoral position is available to study the dopamine transporter (DAT) in Millhauser Labs at New York University School of Medicine, in the group of M.E.A. Reith, involved in structure-function and regulation studies on the neuronal DAT. DAT is the target of psychostimulant drugs of abuse and one of the targets for the development of medications for the treatment of stimulant dependence. We have advanced evidence that DAT oligomerization affects DAT function (see http://myprofile.cos.com/reithm68 and http://www.med.nyu.edu/people/reithm01.html). We will extend these findings with approaches including molecular biology, transporter expression in cell lines, FRET microscopy, immunoprecipitation and western blotting, cross-linking, and functional analysis (dopamine transport and interaction with dopamine derivatives). Applicants should have a Ph.D. in a neuroscience/pharmacology/molecular biology- related field. Please send CV and 3 references (by e-mail) to:
Maarten E.A. Reith, Ph.D.
Departments of Psychiatry and Pharmacology, Room HN-518
NYU School of Medicine
550 First Avenue,
New York,
NY 10016
212-263-8267 | E-mail: maarten.reith@yahoo.com
- Departments of Medicine and Pathology *posted
3/27/08
Immediate postdoctoral scientist position in wound healing/impaired wound healing/translational medicine
Our laboratory discovered that the calcium-binding ER chaperone protein, calreticulin has profound positive biological effects on wound repair. We hold a patent in this usage of calreticulin in [impaired] wound healing and plan to start clinical trials in the near future. We have shown that calreticulin stimulates proliferation and migration of both keratinocytes and fibroblasts and migration of monocytes and macrophages. In addition, calreticulin has recently been shown to be required for the uptake of apoptotic cells and possibly of bacteria. Migration of cells into a wound, proliferation of cells to populate the wound for remodeling, removal of dead cells, and prevention of infection are all critical to successful wound healing. The role of calreticulin in wound healing is an emerging and exciting new field in which the cellular mechanisms involved are unknown. Diabetics have serious impairment of wound healing and we show that calreticulin heals wounds in animal models of impaired healing. Therefore, calreticulin has the potential to improve healing of diabetics. In vitro wound healing, migration, phagocytosis, and proliferation assays will used. Candidates demonstrating the ability to be creative, highly motivated, work independently and with a background in tissue culture and general molecular biology and biochemical techniques should apply. Experience in wound healing, migration, and proliferation assays would be helpful. This position is confined to candidates within the United States.
Please send curriculum vitae and at least three references (by email) to:
Leslie I. Gold, Ph.D.
Associate Professor, Departments of Medicine and Pathology
New York University School of Medicine
550 First Ave. New York, NY 10016.
phone: 212-263-6320 / email: Leslie.gold@med.nyu.edu
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Department of Medicine and Pathology *posted
3/27/08
Postdoctoral scientist position available to study mechanisms involved in loss of growth regulation in human cancers/cell cycle/hormone regulation of growth/tumor microenvironment/translational medicine
An immediate postdoctoral position is available to study mechanisms of loss of growth regulation in endometrial cancer including alterations of cell cycle proteins and the effects of gonadal steroids on growth regulation of the human endometrium through stromal-epithelial interactions. Our studies use cells derived directly from human endometrial tissue in primary cultures and co-cultures. Using these paradigms, we have found that TGF-b, estrogen, and progesterone converge on the cyclin-dependent kinase inhibitor, p27kip1, as a major target to control normal and malignant endometrial growth (Lecanda et al 2007, Can Res). Endometrial cancer is an estrogen-induced cancer that is ameliorated by progesterone, the proposed studies will reveal the mechanisms of action and direct cell cycle effects of hormones and growth factors on endometrial epithelial cell growth. In addition, we show that stromal cells within the tumor microenvironment are phenotypically different from their normal counterparts and secrete factors that enable malignant progression of glandular epithelial cell. These differences have not been identified thereby opening a new and critical field for study. Candidates demonstrating the ability to be creative, highly motivated, work independently and with a strong background in molecular and cell biology, and tissue cultures should apply. Skills in biochemistry and proteomics are also helpful. Highly enriched and interactive basic science environment- a great opportunity. Candidate should be in the United States.
Please send curriculum vitae and at least three references (by email) to:
Leslie I. Gold, Ph.D.
Associate Professor,
Departments of Medicine and Pathology
New York University School of Medicine
550 First Ave. New York, NY 10016.
phone: 212-263-6320 / email: Leslie.gold@med.nyu.edu
- Department of Cell Biology *posted
3/21/08
Available postdoctoral position to study the identification and biology of prostatic stem cells.
A postdoctoral position is available to study aspects of stem cell biology in the prostate gland in the laboratory of Lynette Wilson
Prostatic stem cells and tumor cells have many common features. As stem cells may represent the major target of carcinogenesis and may also play a role in benign prostatic hypertrophy, the isolation and identification of prostatic stem cells is of relevance to both diseases.
We have recently shown that prostatic stem cells are located in a niche in the proximal region of mouse prostatic ducts, express high levels of Sca-1 and are maintained in a quiescent state by generating active TGF-ß in the stem cell niche (J Cell Biol 157, 1257-1265, 2002; J Cell Biol 170; 81-90, 2005; Proc Natl Acad Sci USA 102; 7180-7185, 2005; Stem Cells 24; 1859-1868, 2006). This project will include the isolation of prostatic stem cells and determining if they are targets of transformation. We are also defining the molecules and pathways expressed in the prostatic stem cell niche using microarrays to determine a prostate stem cell gene expression signature. We are isolating prostate tumor stem cells to determine similarities and differences with normal stem cells to develop strategies that target prostate cancer stem cells specifically.
Send CV and 3 references to:
Dr E Lynette Wilson
Department of Cell Biology
NYU School of Medicine
550 First Avenue
New York,
NY 10016
Email: wilsoe01@popmail.med.nyu.edu
Phone 212-263-7684,
Fax 212-263-8139
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Department of Pathology *posted
1/30/08
Available postdoctoral position to work on immunoglobulin gene usage by the neutralizing human monoclonal antibodies against
HIV-1.
A postdoctoral position is available to study the relationship between immunoglobulin (Ig) variable region gene usage of heavy and light chain of human anti-V3 HIV-1 monoclonal antibodies (mAbs) and their neutralizing activity. The human anti-V3 mAbs generated from HIV-1 infected individuals have the capacity to neutralize primary isolates in in vitro assays. The anti-V3 antibodies may play important role in the protection against HIV-1 infection if they are induced by vaccine in the healthy volunteers. The V3 mAbs display diversity in the range of their cross-reactivity and neutralization that may be related to their immunogenetic background. Our preliminary results showed preferential use of one of the Ig gene segment for anti-V3 mAbs and these mAbs display more potent neutralizing activity. The proposed work will examine the relationship between Ig gene usage and function of anti-V3 mAbs available in our laboratory and analyze the repertoire of Ig gene used by anti-V3 antibodies produced by peripheral B cells using a single-cell PCR method.
The position requires experience in molecular biology and immunology.
Please submit your CV and references to:
Miroslaw K. Gorny, M.D., Ph.D.
Department of Pathology
NYU School of Medicine
c/o VA Medical Center
423 East 23rd Street, Room 18149N
New York, NY 10010
Phone: (212) 263-4156
E-mail: mirek.gorny@med.nyu.edu
- College of Dentistry *posted
1/15/08
Postdoctoral scientist positions available to study the microbial diversity of bacterial populations in the human oral cavity.
We seek two qualified candidates for a post-doctoral or associate research scientist position supported by a 5 year R01 grant from the National Institute of Health involving the genetic characterization and diversity of human commensal bacteria in the oral cavity. The position begins February 1, 2008 with renewal for one to five years. Candidates must have a Ph.D., preferably in molecular biology or microbiology, with at least one year of post-doctoral experience.
Candidates must possess relevant backgrounds in molecular biology dealing either with bacterial pathogenesis and bacterial diversity/ecology. The position requires hands-on mastery of DNA sequencing, subtractive DNA hybridization, cloning and expression systems, gene expression and characterization, together with working and theoretical knowledge of bioinformatics and computer use.
Salary is competitive and is commensurate with experience. NYU is well located in mid-Manhattan, New York City.
Please submit your CV along with contact information of three references to pwc2@nyu.edu with the subject line “post doc applicant.”
Page W. Caufield, D.D.S., Ph.D.
NYU College of Dentistry
345 E. 24th St. Rm. 1024
New York, NY 10011
page.caufield@nyu.edu
- Department of Pathology *posted
1/10/08
Postdoctoral positions in the immunobiology of pregnancy and peripheral immune
tolerance.
We are inviting applications for postdoctoral positions to study mechanisms
of maternal immune tolerance towards the allogeneic fetus, and how these
mechanisms might relate to broader issues of peripheral immune tolerance and
tumor immunology. The project is NIH-funded and involves a broad range of
whole-animal, cellular, and molecular techniques. Expertise in cellular
immunology is desirable. The applicant must be available for an interview.
Please e-mail a cover letter, CV, and list of references to:
Adrian Erlebacher, MD PhD
Department of Pathology
Division of Experimental Pathology
NYU School of Medicine
Smilow Research Center, Room 311
550 First Avenue
New York, NY 10016
E-mail:adrian.erlebacher@med.nyu.edu
- Department of Physiology and Neuroscience *posted
12/15/07
Available postdoctoral position to work on experimental myelin pathology and neuroglial interactions.
This post-doctoral position is available in the laboratory of Dr. Jack Rosenbluth working on experimental myelin pathology and neuroglial interactions. A background in microscopy, including fluorescence immunocytochemistry, confocal and TEM, and cell/tissue culture is desirable. A year of experience in myelin-related projects is preferred. This is an opportunity for collaborative work involving cell biology, electrophysiology and molecular biology.
Please submit your CV, contact information and references to: rosenj03@med.nyu.edu with the subject line “Postdoc Applicant.”
- Department of Anesthesiology *posted 12/06/07
Available postdoctoral fellowship available to study physiological role of sialic acids using both primary neurons and an in vivo Drosophila model.
A postdoctoral fellowship position is available in the laboratory of Dr. Esperanza Recio-Pinto. The candidate will work in an interdisciplinary project studying the physiological role of sialic acids using both primary neurons and an in vivo Drosophila model. The Drosophila model displays neurological defects (paralytic behaviors) following a decrease in sialic acid expression. The candidate will carry out electrophysiological measurements both in isolated neurons from Drosophila (wild type mutants) as well as in CHO cells expressing various Drosophila channels. Background experience in tissue culture and electrophysiological techniques is preferred.
Interested candidates should submit their CV to: erecioe02@med.nyu.edu
- Department of Microbiology *posted 10/09/07
Available postdoctoral position is available to study the role of liver X receptor (LXR) in macrophage gene regulation and cardiovascular disease.
A postdoctoral position is available in the laboratory Dr. Michael Garabedian to study the role of liver X receptor (LXR) in macrophage gene regulation and cardiovascular disease. The applicant must be a recent PhD graduate. The position requires previous research experience in transcriptional regulation, cell and molecular biology and a strong publication record. Background in nuclear receptor signaling is desirable, as is experience with mouse models. Initial salary is commensurate with experience; application for independent funding is strongly encouraged. Dr. Garabedian is committed to mentoring post docs and has a proven track record of moving them onto the next phase of their career.
Please submit your CV along, and contact information of three references to garabm01@med.nyu.edu with the subject line “post doc applicant.”
NYU is an equal opportunity employer fostering
diversity in the workplace.
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