The following projects are currently ongoing or completed during the last three years at the NYU School of Medicine Sleep Disorders Center:

• Relating Sleep Disordered Breathing to Daytime Function.
• Validation of Apnea Risk Evaluation System Sleep Scoring. 
• Neurocognitive Profiler: High efficiency brain behavior integrated assay.
• Development of Novel Form of Self Titrating CPAP.
• Pillar palatal implant system/CPAP clinical study.
• Nasal Valve Therapy for Obstructive Sleep Apnea: Evaluating physiologic and clinical parameters.
• A pilot study evaluating changes in Pcrit after therapy for OSA with oral appliance therapy and upper airway training.

Relating Sleep Disordered Breathing to Daytime Function
Agency: NIH-NHLBI R01 HL081310
PI: Indu Ayappa

This study aims to develop a novel metric of obstruction including the AHI and sustained flow limitation and relating it to the severity of daytime dysfunction.

Validation of Apnea Risk Evaluation System Sleep Scoring         
Agency: NIH-SBIR R44 HL068463
PI: Dan Levesdowski
NYU PI: Indu Ayappa

This SBIR compares the EEG based sleep scoring in an ambulatory monitor with laboratory PSG.

Neurocognitive Profiler: High efficiency brain behavior integrated assay
Agency: NIH-SBIR R43 MH078436  
PI: Chris Berka            
NYU PI: David M. Rapoport

This SBIR evaluates a portable device which monitors alertness and assess neurocognitive behavior in normals and sleepy subjects.

Development of Novel Form of Self Titrating CPAP                                  
Agency: Fisher-Paykel HealthCare
PI: David M. Rapoport

This project is a collaboration to develop a CPAP system which responds the state of alertness of the subject and automatically adjusts the pressure to minimize the effects of anxiety and alertness on autotitration.

Pillar palatal implant system/CPAP clinical study
Agency: Restore Medical
PI: David M. Rapoport

This project  is a multicenter trial of the Pillar palatal implant on the optimal CPAP pressure and compliance with CPAP. NYU serves as both recruiting site and central reading site.

Nasal Valve Therapy for Obstructive Sleep Apnea:  Evaluating physiologic and clinical parameters.
Agency: Ventus, Inc.
PI: Dennis Hwang

This project evaluates the mechanism of action of a new mode of therapy for  obstructive sleep disordered breathing by providing nasal end expiratory pressure.  

A pilot study evaluating changes in Pcrit after therapy for OSA with oral appliance therapy and upper airway training.
Agency: American Sleep Medicine Foundation
PI Dennis Hwang
Mentor: David M. Rapoport

This project will compare the effect of oral appliances and training with playing the didgeridoo on the Pcrit as a measure of upper airway collapsibility in OSA.